Buses and related are great in SA. I'm frankly surprised that it took 11 separate buses to this
If you are a comfortable traveler and know a bit of spanish, find the combis/collectivos wherever you are, it is far and away the best way to do day trip travel from many cities
But that's still after the decision was made... I guess it's still useful. But maybe that person didn't actually weigh a decision and tradeoffs when they made the change.
This problem goes away when you have school choice, which a majority of states either have today or will have in the next few years. Some other states like Illinois have no desire for that though.
lol yes what we really need right now is unregulated interstate sales of raw milk. Luckily that was introduced in 2024 (last congress) and went nowhere.
What's interesting to me is that one of the biggest booms in pharma over the last ~10 years has been biologics / monoclonal antibodies that treat auto-immune diseases by SUPRESSING cytokines. Examples include TNF inhibitors like Remicade/Humira/Enbrel; or specific IL-XX inhibitors like Dupixent/Cosentyx/Skyrizi/Tremfya/etc; or interferon therapies for MS. These are increasingly used for a broad (unlimited?) set of autoimmune or inflammatory diseases and work by blocking specific cytokines to reduce immune overactivity.
What this treatment does is the opposite side of that coin, it mimics cytokines in order to PROMOTE an immune response.
Immune regulation is an area that deserves a lot more research, and there is going to be learning (harm) along the way. An increasing body of science is pointing to autoimmune diseases being triggered by traditional vaccines, which are then treated by the biologics above that increase the likelihood of other disease due to immunosuppression, which can now be treated(?) by a new immunobooster AKA universal vaccine?
I would like to see the "increasing" body of evidence pointing towards traditional vaccines.
My wife has an autoimmune disease. Most all the evidence points towards gut biome but that shit is super complicated. We have very little research into what our gut biome needs to be.
If you want to continue to believe that vaccines come with no issues, you will find more than enough evidence to support that belief. I'm not here to dissuade you of that. If you are open to considering other possibilities, look into molecular mimicry and immune crossreaction, adjuvants and ASIA syndrome, bystander activation and epitope spreading, MMR and ITP, and the Guillain Barre syndrome studies
So much of this started with the rise of the peer-review journal cartel, beginning with Pergamon Press in 1951 (coincidentally founded by Ghislaine Maxwell's father). "Peer review" didn't exist before then, science papers and discussion was published openly, and scientists focused on quality not quantity.
I'm not sure that the system was ever that near to perfection: for example, John Maddox of Nature didn't like the advent of pre-publication peer review, but that presumably had something to do with it limiting his discretion to approve and desk-reject whatever he wanted. But in any case it (like other aspects of the cozy interwar and then wartime scientific world) could surely never have survived the huge scaling-up that had already begun in the post-war era and created the pressure to switch to pre-publication peer reivew in the first place.
"The crises that face science [from the ending of exponential growth in science funding after the Cold War period] are not limited to jobs and research funds. Those are bad enough, but they are just the beginning. Under stress from those problems, other parts of the scientific enterprise have started showing signs of distress. One of the most essential is the matter of honesty and ethical behavior among scientists.
The public and the scientific community have both been shocked in recent years by an increasing number of cases of fraud committed by scientists. There is little doubt that the perpetrators in these cases felt themselves under intense pressure to compete for scarce resources, even by cheating if necessary. As the pressure increases, this kind of dishonesty is almost sure to become more common.
Other kinds of dishonesty will also become more common. For example, peer review, one of the crucial pillars of the whole edifice, is in critical danger. Peer review is used by scientific journals to decide what papers to publish, and by granting agencies such as the National Science Foundation to decide what research to support. Journals in most cases, and agencies in some cases operate by sending manuscripts or research proposals to referees who are recognized experts on the scientific issues in question, and whose identity will not be revealed to the authors of the papers or proposals. Obviously, good decisions on what research should be supported and what results should be published are crucial to the proper functioning of science.
Peer review is usually quite a good way to identify valid science. Of course, a referee will occasionally fail to appreciate a truly visionary or revolutionary idea, but by and large, peer review works pretty well so long as scientific validity is the only issue at stake. However, it is not at all suited to arbitrate an intense competition for research funds or for editorial space in prestigious journals. There are many reasons for this, not the least being the fact that the referees have an obvious conflict of interest, since they are themselves competitors for the same resources. This point seems to be another one of those relativistic anomalies, obvious to any outside observer, but invisible to those of us who are falling into the black hole. It would take impossibly high ethical standards for referees to avoid taking advantage of their privileged anonymity to advance their own interests, but as time goes on, more and more referees have their ethical standards eroded as a consequence of having themselves been victimized by unfair reviews when they were authors. Peer review is thus one among many examples of practices that were well suited to the time of exponential expansion, but will become increasingly dysfunctional in the difficult future we face.
We must find a radically different social structure to organize research and education in science after The Big Crunch. That is not meant to be an exhortation. It is meant simply to be a statement of a fact known to be true with mathematical certainty, if science is to survive at all. The new structure will come about by evolution rather than design, because, for one thing, neither I nor anyone else has the faintest idea of what it will turn out to be, and for another, even if we did know where we are going to end up, we scientists have never been very good at guiding our own destiny. Only this much is sure: the era of exponential expansion will be replaced by an era of constraint. Because it will be unplanned, the transition is likely to be messy and painful for the participants. In fact, as we have seen, it already is. Ignoring the pain for the moment, however, I would like to look ahead and speculate on some conditions that must be met if science is to have a future as well as a past. ..."
The paper may have a point in that the internet makes possible a certain scale of deception via paper mills and brokers and such -- but the motivation to use the internet that way comes from the growing financial pressures that Dr. Goodstein identified.
Fun fact, he almost got the worldwide console rights to Tetris back in the 80s, and tried going to Soviet officials to get those rights. To the point he's the antagonist of a recent "Tetris" movie that came out.
I believe by saying it is coincidental they are saying there is probably no relevance, just an interesting piece of trivia, why put out this interesting piece of trivia? Because maybe someone will be able to make an argument of relevance.
Ghislaine's father (Robert Maxwell) was also a terrible person but for different reasons.
Robert Maxwell was a crook, he used pension funds (supposed to be ring-fenced for the benefit of the pensioners) to prop up his companies, so, after his slightly mysterious death it was discovered that basically there's no money to pay people who've been assured of a pension when they retire.
He was also very litigious. If you said he was a crook when he was alive you'd better hope you can prove it and that you have funding to stay in the fight until you do. So this means the sort of people who call out crooks were especially unhappy about Robert Maxwell because he was a crook and he might sue you if you pointed it out.
I imagine it's the interesting peculiarity that the same people seem to crop up over and over and over again. Six degrees of Kevin Bacon or something, except it's like one or two degrees. As George Carlin said, "it's a big club, and you ain't in it"
For example Donald Barr (father of twice-former US Attorney General Bill Barr) hiring college-dropout Jeffrey Epstein whilst headmaster at the elite Dalton School
Additional fun facts about Donald Barr: he served in US intelligence during WWII, and wrote a sci-fi book featuring child sex slaves
Also the Epstein-Barr virus causes Mono, the clone of .NET, which was created by Bill Gates, known associate of Epstein, whose father was president of the Washington State Bar Association. And you know who else works in Washington? Join the dots, people.
We call people who make connections like these "conspiracy theorists," until they're right, at which point we call them "right". And somewhere in between, if they manage to get a job, we call them "Simpsons writers."
If you want to know more about the history of Pergamon Press there's a great Behind the Bastards episode on Robert Maxwell (Ghislaine Maxwell's father) - who himself was a scumbag in a variety of ways that were entirely distinct from Ghislaine Maxwell's brand of scumbaggery - that covers this. Might even be a multipart episode - it's a while since I've listened to it, but I have a feeling it's at least a two parter.
"Coincidental" means random, with no causal connection being explicitly claimed. It just means that two things share some characteristic (such as being relatives.) The thing that is coincidental is that the person who founded the company being discussed is also the father of another person who current events have brought into prominence.
It's why you would say something like "more than coincidental" if you were trying to make some causal claim, like one thing causing the other, or both things coming from the same cause.
So, "What is coincidental about that?" is a weird question. It reads as a rhetorical claim of a causal connection through asking for a denial or a disproof of one.
what is the relevance to the discussion about journals and peer review is my main question.
if i randomly mentioned that your name appears to be an alternate spelling of a 3-band active EQ guitar pedal, coincidentally sharing all of the letters except one, in my reply to you, most people would be confused. that is how i felt when randomly reading "Ghislaine Maxwell" in this context of journals and peer review.
What is currently called "peer review" didn't exist back then, back then the meaning of "peer review" was just the back and forth happening in the open academic literature. Note the inevitable lack of finality in the original concept of peer review, a discussion in the scientific community could go on for 100's of years before being finally resolved. The current concept of "peer review" is closer to the concept of a delegation of some opaque ministry of truth composed of some opaquely selected experts (who often truly intend well) to settle in a short duration the finality.
Some measurements or experiments or questions to be settled can be very actionable and provide highly accurate results, others require much longer gathering of data to draw a clear picture.
The modern concept of "peer review" tries to sell the idea of almost immediate finality, like an economic transaction. In reality it is selling just the illusion, and creating lots of victims ranging from truth, individuals, departments institutions, or even entire fields (think of the replication crisis in psychology) along with any patients or others they treat.
I know a PhD professor doing post doc or something, and he accepted a scientific study just because it was published in Nature.
He didn't look at methodology or data.
From that point forward, I have never really respected Academia. They seem like bottom floor scientists who never truly understood the scientific method.
It helped that a year later Ivys had their cheating scandals, fake data, and academia wide replication crisis.
When I read something in a textbook I blindly believe it, depending on the broader context and the textbook in question. Is that a bad thing?
People are constantly filtering everything based on heuristics. The important thing is to know how deep to look in any given situation. Hopefully the person you're referring to is proficient at that.
Keep in mind that research scientists need to keep abreast of far more developments than any human could possibly study in detail. Also that 50% of people are below average at their job.
There is a vast difference between a student reading from a textbook and a researcher / scientist reading studies and/or papers.
As a student you are to be directed* in your reading by an expert in the field of study that you are learning from. In many higher level courses a professor will assign multiple textbooks and assign reading from only particular chapters of those textbooks specifically because they have vetted those chapters for accuracy and alignment with their curriculum.
As a researcher and scientist a very large portion of your job is verifying and then integrating the research of others into your domain knowledge. The whole purpose of replicating studies is to look critically at the methodology of another scientist and try as hard as you can to prove them wrong. If you fail to prove them wrong and can produce the same results as them, they have done Good Science.
A textbook is the product of scientists and researchers Doing Science and publishing their results, other scientists and researchers verifying via replication, and then one of those scientists or researchers who is an expert in the field doing their best to compile their knowledge on the domain into a factually accurate and (relatively) easy to understand summary of the collective research performed in a specific domain.
The fact is that people make mistakes, and the job of a professor (who is an expert in a given field) is to identify what errors have made it through the various checks mentioned above and into circulation, often times making subjective judgement calls about what is 'factual enough' for the level of the class they are teaching, and leverage that to build a curriculum that is sound and helps elevate other individuals to the level of knowledge required to contribute to the ongoing scientific journey.
In short, it's not a bad thing if you're learning a subject by yourself for your own purposes and are not contributing to scientific advancement or working as an educator in higher-education.
* You can self-study, but to become an expert while doing so requires extremely keen discernment to be able to root out the common misconceptions that proliferate in any given field. In a blue-collar field this would be akin to picking up 'bad technique' by watching YouTube videos published by another self-taught tradesman; it's not always obvious when it happens.
> There is a vast difference between a student reading from a textbook and a researcher / scientist reading studies and/or papers.
Not really. Both are learning new things. Neither has the time or access to resources to replicate even a small fraction of things learned. Neither will ever make direct use of the vast majority of things learned.
Thus both depend on a cooperative model where trust is given to third parties to whom knowledge aggregation is outsourced. In that sense a textbook and prestigious peer reviewed journals serve the same purpose.
Papers in any journal (even or especially Nature, depending on your prior) should have a significantly larger degree of skepticism shown towards them than statements in reputable textbooks (which also should not be taken as complete gospel). Papers are a 'hey, we did a thing once, here's what we think it means' from a source that is very strongly motivated to do or find something novel or interesting, even if you trust that there is no fraud they are not something to approach uncritically.
> If you fail to prove them wrong and can produce the same results as them, they have done Good Science.
Not really in my humble opinion. Sure, the Popperian vibe is kind of fundamental, but the whole truncation into binary-valued true/false categories seldom makes sense with many (or even most?) problems for which probabilities, effect sizes, and related things matter more.
And if you fail to replicate a study, they may have still done Good Science. With replications, it should not be about Bad Science and Good Science but about the cumulation of evidence (or a lack thereof). That's what meta-analyses are about.
When we talk about Bad Science, it is about the industrial-scale fraud the article is talking about. No one should waste time replicating, citing, or reading that.
This is a good point. It is not humanly possible to verify every claim you read from every source.
Ideally, you should independently verify claims that appear to be particularly consequential or particularly questionable on the surface. But at some point you have to rely on heuristics like chain of trust (it was peer reviewed, it was published in a reputable textbook), or you will never make forward progress on anything.
> When I read something in a textbook I blindly believe it, depending on the broader context and the textbook in question. Is that a bad thing?
It is if what you read is factually incorrect, yes.
For example, I have read in a textbook that the tongue has very specific regions for taste. This is patently false.
> Keep in mind that research scientists need to keep abreast of far more developments than any human could possibly study in detail. Also that 50% of people are below average at their job.
So, we should probably just discount half of what we read from research scientists as "bad at their job" and not pay much attention to it? Which half? Why are you defending corruption?
The problem is that you can't just verify everything yourself. You likely have your own deadlines, and/or you want to do something more interesting than replicating statistical tests from a random paper.
Yes? What is exactly funny here? This is literally how the civilization works. I'm paid to do my work, and I pay others to do their work.
Do you grow your own food and sew your own clothes? Also, did you personally etch the microprocessor that runs your computer? The division of labor inherently means trusting others. So when I buy a bag of M4 screws, I'm not going to measure each screw with a micrometer, and I'm not taking X-ray spectra to verify their material composition.
The academic world also used to trust large publishers to take care to actually review papers. It appears that this trust is now misplaced. But I don't think it was somehow stupid.
>The problem is that you can't just verify everything yourself..
But one should be free to reject (in the sense that they should be free not to depend on it, or take decisions based on it) things that they did not themselves verify. But today if you do that, you become "anti-science"...and in-fact the people who wants others to "believe" science is anti-science..
Most of the times you don't "accept" results. You have to build something on them, like an extension or a similar version on other field. So usually the first step is try to understand the cryptic published version and do a reproduction or something as close as possible.
The exact reproductions is never published, because journals don't accept them, but if you add a few tweaks here and there you have a nice seed for an article to publish somewhere.
(I may "accept" an article in a field I don't care, but you probably should not thrust my opinion in fields I don't care.)
Academia has problems, like everywhere else. But that seems like a big extrapolation from just one professor.
Fake data—you can only get that type of scandal when people are checking the data. I’d be more skeptical of communities that never have that kind of scandal.
In this case, the problem is a bit easier to identify and solve. Specifically, the Q-rating and publish or perish system is at fault. That can be fixed, or at least improved. Maybe we should be doing that instead of denying the obvious problems.
tl;dr He is the bridge that uncomfortably links Biden's former Secretary of State, Antony Blinken, to Jeffrey Epstein and Mossad. Hence, *gestures at the last couple of weeks and years*. Dude was just, like, Fraud Central, apparently.
Assuming the corner radius scales with the size of the window, there is an argument to be made (I won't sign onto it) that the different corners actually give you additional useful information about which window each belongs to, helping you select the right one.
Yeah makes sense though. And for those reading Persian lime is the regular lime found in US grocery stores. Kaffir lime (one of the cornerstone species not included on the ternary axes) is the lime used in Thai food
Corporate speak as a signalling mechanism is only effective among the "clueless" in the Gervais model. If any CEO tried to talk 1:1 to a competent board member that way, they would lose all credibility. Once you've operated at a certain level you get it
>a system for turning bullshit into parse errors.
This is the (cynical version of) the framing I tend to hold about corporate speak. It's deliberately vague as a way to navigate uncertainty while still projecting authority and avoiding accountability in settings like a town hall, large meeting etc. Which is not to be read as a necessarily "bad" thing. No one wants a micromanaging CEO. They have to set vision and direction while leaving space for it top be executed by all the layers under them
Corporate speak as a signalling mechanism is only effective among the "clueless" in the Gervais model. If any CEO tried to talk 1:1 to a competent board member that way, they would lose all credibility. Once you've operated at a certain level you get it
This also holds true for competent non-board members. I have interacted with C-level executives at fortune 100 companies, as well as smaller businesses. It is almost impressive how quickly they can switch in and out of corporate bullshit mode. I think it's what the kids call code-switching.
In general, once they trust you a bit, and they know someone isn't listening they talk like a normal person. Then you ask a difficult question about the business and the corporate-speak kicks in like a security sub routine trying to prevent them from saying the wrong thing.
I have also met some that seemingly calculate their tone and cadence to try to manipulate the person(s)/people(s) they're talking to. It's fascinating when you catch them doing it, and it's different than simply matching like a chameleon. For example, they may use an authoritative tone with younger people, a kind but subtly threatening tone with anxious people, and a buddybuddy tone with a plumber or someone they know isn't going to put up with any bullshit.
I'm really curious how much of it is formally taught in MBA programs and stuff, how much is them copying each other, and if any of it is just a natural defense mechanism to the pressures of being in power.
Ultimately I think all of what you describe there falls into a bucket of personality traits and social skills that contribute to success in many areas of life.
It's some combination of what they call "self monitoring" in social psychology, plus general EQ and Machiavellian personality traits that allow people to read the room and adjust their tone, speaking style, word choice (including picking up in-group lingo quickly), posture etc to be most effective given the setting. This applies to basically any social environment, and is often a frustrating reality to many people who may be extremely competent but see others around them who are obviously less competent "getting ahead" through social acumen, office politics etc.
The higher up you are in a company the more of “yourself” you have to give as realistically many more people are relying on your job results than they are on your personal wellbeing.
It definitely takes a certain kind of person to be a good fit in that role
The polite term these days is "sociopath", which takes out the whole "psycho-killer" weightedness (because a sociopath can be very likeable and friendly) - and they fill the ranks of leadership in all professions...
Haven't there also been many studies that show high-level executives also have a high number of "sociopaths" in their ranks?
Sociopaths can code-switch instantly - I wonder how much of this is training, versus emulating others, versus a fundamental difference in brain operations...
The Gervais model is predicated on sociopathy as the driving force of social cohesion. This is the kind of model a sociopath would construct. There are other models available to us.
Social organizations require some sort of glue to bind them together. They need ways to maintain cohesion despite vagueness and to obscure (small) errors. There is a cap put upon max individual output, but aggregate output is much higher than whatever a collection of individuals could attain. This is a very basic dynamic that is lost amidst a cult of individualism that refuses to admit to any good greater than themselves.
Yes - the CEO talking to the board in this way would lose credibility. But a CEO failing to deploy this jargon correctly would also lose credibility with the board : it's obvious he doesn't know how to lead.
What I would like to see is a study of the ratio's between corporate speak and technical speak - and the inflection points at which too much of either causes organization ruin.
Is there a historical example or does anyone have an anecdote of some crunch time where the CEO blowing hot air was the best thing for morale? Compared to what I might think a lot of us would prefer in many cases, which might be an honest assessment & making us part of the journey to overcome whatever adversity.
"an honest assessment & making us part of the journey to overcome whatever adversity"
I suspect that most people just aren't wired up that way - we have a natural tendency to want to follow leaders and what we seem to want most from leaders is certainty and confidence. Does it matter what leaders are certain and confident about - not really.
It is hard to argue with a vague statement like "most people" without a proper scientific study. But I disagree: following the scientific principle, and being willing to change opinion in the face of new evidence increases my trust in someone. Someone who is certain and confident without showing their work / sources make me suspicious. And critical thinking is (pardon the pun) a critical skill.
If you actually think and act that way, so much the better. I don't even particularly disbelieve you. But can you really look at the mass of humanity around you and believe they think the same way? Even if they claim to value critical thinking, watch what they do, what they buy, how they vote.
You've most likely trained yourself to value critical thinking in your leaders, most likely from an early enough age that you don't remember what it was like without it. Lots of people don't get this training or don't apply it in a fully general way.
Hm, having a journalist and an academic (with a heavy focus on applied rigorous statistics) as parents probably helped there, you are right. But school is supposed to teach this, at least here in Sweden it is a part of the curriculum. But indeed, that doesn't seem to help, and the US it is especially bad (not saying the situation is good here either though).
There are other things I do remember having to train myself to do though, such as not make value judgments based on the language skill level of others. Rationally I have never cared where someone is from and if they are a native speaker or not, but emotionally that required some effort.
I'm not convinced it's actually possible to teach critical thinking to someone who doesn't care, but I'm glad your schools are trying harder.
But even when people are trained in critical thinking, the part at the end of my comment about applying it in full generality is also critical. You have to be emotionally ready to apply it in cases where it produces unpleasant conclusions, not just for your job or when it helps dunk on your political opponents. Also difficult to impossible to teach at scale.
Let's say there are a thousand people there at the town hall. You don't want any of them to leave upset, or even concerned. But they each have different things that will make them concerned and upset. So there are maybe 10,000 tripwires out there, and you don't want to trip any of them.
So you're not being dishonest, exactly. You're being nonspecific. You don't want to get down in the weeds and nail down the answer too tightly, because you may trip someone's tripwire. (And also because it would take to long.) So you say something true but not very specific.
(I mean, there can be dishonesty, too, but that's a different thing. Smooth vagueness can still be honest, just unsatisfyingly vague.)
"Smooth vagueness" to me comes off as tautologies. If you cannot say anything specific it means either you don't know, or don't want others to know. So it is a lie about ones' competency, or a lie by omission.
If you are a comfortable traveler and know a bit of spanish, find the combis/collectivos wherever you are, it is far and away the best way to do day trip travel from many cities
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