Nah, my audio interface is more exotic. Thunderbolt MOTU 16 channel in and out, 192k/24. So I love that it has so many thunderbolt ports, because they're spoken for. I think you might well be able to run two MOTU 16As and have 32 in, 32 out. You'd start to have issues with drive space but the computer can probably handle it.
Yeah, that's a bit beyond my hobby "Behringer" type stuff. Recently upgraded from 2-in/4-out to 4-in/4-out. Still plenty of bandwidth on USB 2 for that.