I've used a few retina Macs to do various kinds of web dev. Firefox tends to do some things fastest (eg: re-layout when resizing the window), some things the slowest (eg: certain large, complex CSS animations). For most things, it's perceptually equivalent to Chrome or Safari. Some things that are fast/good in Chrome will be slow/bad in FF, and vice versa. The biggest shortcomings I currently face are (1) a lot of banding when layering lots of complex gradients, due to a poor job of dithering and (2) weird handling of certain colors on my P3 display due to the assumption that colors are in the full display space rather than sRGB.
A big problem of early Quantum Firefox on HiDPI Macs was its high battery usage. I think it got slightly better with later releases, but I don't have data to support that.
I have never run my MacBook Pro in anything but the default scaling resolution. Quantum has been and continues to be a nightmare on my device. Unusably slow performance with high CPU utilization and occasionally spiking CPU utilization to 100% for prolonged periods. Usually long enough that I am forced to reboot the laptop.
Unfortunately, a non-native scaling mode is the default on new Mac laptops now. You need to switch to one of the custom scaling modes to get a true, native 2x.