The Iran political situation is not exactly about to topple, but it's not the most stable situation in the world, either. Four-plus years is a really long time when we're talking about the CIA's/US's/Israel's ability to topple a potentially vulnerable regime.
Perhaps we'll be as successful as we were in Cuba! Or maybe North Korea! Or Iraq....We've only been trying to overthrow the government in Cuba for, oh, about half a century. I'm sure we'll nail it any day now. True, Cuba is 90 miles from the US and we've got millions of spanish speakers, so toppling the Iranian government should be a piece of cake given how many Farsi speakers work for the US government!
Even if we were successful, what makes you think alternate Iranian regimes would differ on nuclear policy from the current one? Or is the plan to replace the current regime with another brutal dictator who will have zero popular legitimacy? After all, that's worked out so well for us in the past....
Finally, has Israel ever successfully toppled a regime anywhere in the world?