I don't think there is a computer in the world that has a worse uptime than myself. Even old cheap Windows ME boxes did a fair enough job of being able to run without impairment for more than 20 hours or so.
The complexity of the applications will be far greater than Windows ME. Good article on The Long, Dismal History of Software Project Failure - http://www.codinghorror.com/blog/2006/05/the-long-dismal-his.... Before we let everyone's self-driving mashup on the road it might be good to figure out if they work first.