It's a personal taste thing I think. I've never been a fan of small mice myself.

For me, something like the Logitech Performance MX was the peak in terms of mouse comfort, allowing a natural palm grip. It had a couple of useful extra buttons by the thumb, and a few other controls I never used that weren't intrusive. I swore by those things for years and had them on every PC I used regularly.

More recent Logitech models have added a second wheel by the thumb for horizontal scrolling, which I do like. Sadly they also come with a long list of regressions. They try to be too clever with the main scroll wheel. They've added other controls that are easy to trigger unintentionally. Most importantly, the sensors really seem to struggle with some common surface types, something that was never an issue for me with the earlier models.

Somehow the shape for the later models has never quite matched the Performance MX generation either. For me they are mostly either too small for a comfortable palm grip or using some strange spiral effect that makes the middle part too high for comfort in prolonged use. I wonder if the spiral ones are meant to fit the claw grip popular with serious gamers. And the models like the MX Master that were supposed to be an improved Performance MX style somehow never quite fit either, though I struggle to put my finger on why that was.

I still use Logitech mice for most things, because they seem to be the best of a bad bunch for me at the moment. But I'd throw them all out in an instant if I could have the one I actually liked back again.