I have used a PiHole ever since I learned that LittleSnitch resolves DNS queries (to IP) before the dialog prompts whether to Allow/Deny a connection to the unlisted host. It is an added bonus that I can route my entire subnet to the local PiHole, which prevents rogue software/OS/devices/phones from initiating undesired connections. If you know how to make a few simple IPfilter rules, you can even stop hard-coded devices (e.g. smart TVs) from phoning home with internal DNS IP addresses — all you have to do is capture all DNS queries, IPs included.

Simply blocking pagead2.google.com and googlesyndicate.com will remove 50%+ of website advertising. ReGex rules allow for ads.* (etc.), and these rules apply on your entire local network. For an added bonus, you can then use your local PiHole to resolve DNS queries remotely (e.g. from your phone) — just all around an incredible product!

/r/PiHole

How do you keep the level of service from PiHole once you leave your local network?

Run it locally on docker.

On a mobile device?

You might be able to using tmux, if you are on apple you might be out of luck, unless you want to run it on a server and set your DNS to it.

Was thinking more in the vein of similar but different to PiHole on a cloud instance. Connect as a VPN. Not sure how much lag that would introduce, and if you could use it in place of pihole for local network at home as well. Set it up once, use it for everything.

Probably not as cheap as a Pi, but more beneficial. blah blah. decisions! yay!

I have wireguard set up so that all traffic is routed through my home network

Ublock will get you 99% of the way there tho unless for some reason you're stuck using chrome. Then usually brave or vivaldi will fill in the gap. Avoid chrome always.