How are you reloading your Python application on code changes? Are you just working inside the VM? I've tried VirtualBox shared folders and NFS, and never had any luck getting file change events to propagate from my host to the VM.
Shared folders work well for me & everyone else on me team. Perhaps you should file a ticket for your issue?
Also, if you use port forwarding for all your databases etc. then you could technically just run Python code on your host computer. Indeed, I do this myself usually -- I treat the Vagrant box more like a "deployment target" that just happens to also run the DBs I can use for local testing.
I, too, have had problems. In my case it's an OSX host, Ubuntu client.
Most of my python work isn't webdev so I've never had an issue with it in python but other daemons that do this sort of thing -- Brunch for example -- have given me intermittent trouble. I never did figure it out.
