I don't mean to belittle Python here, I think its a great language and I find its unpacking useful. I'm only trying to demonstrate that the concept can be (and is in some other languages, like Clojure) taken further to make it more useful still.
I think that Python's unpacking allows most, if not all, of Clojures sequence destructuring for tuples and lists. Clojure takes it a bit further, however, by applying it to all sequences. For example, you could do this:
a,b,c = "XYZ"
because strings are also sequences. You can also do something like this (excuse the awkward syntax as I try to express it in pseudo-Python):
a,b : c as d = [1,2,3,4,5]
# a = 1
# b = 2
# c = [3, 4, 5]
# d = [1, 2, 3, 4, 5]
This might not be so useful in python, since the list already is d and c is simply slicing the end from the list, but Clojure allows you to destructure function arguments: (defn foo [[a, b & c :as d]] ...) when passed the above list (foo [1 2 3 4 5]) would bind the variables as shown in the above comments.
Where destructuring really shines, though, is that you can destructure maps (dictionaries in Python) and vectors can also be treated as maps (their keys are the indices), so you can do stuff like this:
a, {[b {:keys [c, d]} :foo}, e = [1, {foo: [2, {c: 3, d: 4}, bar: 9}, 5]
# a = 1
# b = 2
# c = 3
# d = 4
# e = 5
