There's nothing profound about it, it's common sense in business though people use different words like "moats", "barriers to entry" and "pricing power".
Well it doesn't help that the startup world thumbs their nose at MBAs and seems to really want 26 year old founders. Inexperience + disdain for the very education that teaches that kind of thinking leads to a pretty obvious conclusion.
> one of the most profound insights in Thiel's excellent book, Zero to One.
Which was an insight in Blue Ocean Strategy (Kim & Mauborgne, 2005).
And before that, if you squint, in Competitive Strategy (Porter, 1980) and Competitive Advantage (Porter, 1980).
And the B-school theorists basically got their ideas by peeking over the fence of the Economics dept at how monopolies are formed and abuse their power and saying "hey, let's teach that to our students".
This move just deepens YC's monopoly in its domain, as sama would say, "in the Peter Thiel sense."