Yes, several actually with a more or less drop-in replacement for anything from 3 to 12 cylinders, it mostly depends on how much work you want to do adapting a particular piece of hardware to the sensors and actuators on your engine. That's the hard part, once you have reliable sensor data and ways to create reliable output it's mostly configuration work and you're good to go.

Off the top of my head, non-free licenses:

- AEM

- Haltec

- MegaSquirt

- Motec

- Profec

Free licenses:

- Speeduino

- RusEFI

And probably many others.

There are also special units designed for the race track folks.

Speeduino is the open-source (as in hardware and software) solution. Megasquirt is most definitely not open.

https://megasquirt.info/ is one (and one of the most well-known).

I've considered doing a retrofit on a classic Mustang V8, but the old-school carb works well enough that it's not been a priority.

Edit: sibling comment correctly identifies the code as not open-source. (I could have sworn it was; perhaps it started that way, or perhaps the amount of open it was when I last looked in detail was sufficient for my plans.)

As mentioned in another answer, megasquirt. I used the first generation one to retrofit injection to my carburated rally car with home made manifold and repuposed injection throttle bodies from a gpz 1100. Even badly self tuned it worked better than the carb did.