Yes, several actually with a more or less drop-in replacement for anything from 3 to 12 cylinders, it mostly depends on how much work you want to do adapting a particular piece of hardware to the sensors and actuators on your engine. That's the hard part, once you have reliable sensor data and ways to create reliable output it's mostly configuration work and you're good to go.

Off the top of my head, non-free licenses:

- AEM

- Haltec

- MegaSquirt

- Motec

- Profec

Free licenses:

- Speeduino

- RusEFI

And probably many others.

There are also special units designed for the race track folks.